【摘要】 目的探讨原肌球蛋白(TM)表达与胃癌晚期不同证型的相关性。方法经胃部组织活检确诊的胃癌晚期患者41例(脾胃虚寒型23例,胃热伤阴型18例)和浅表性胃炎患者(对照组)15例,均应用免疫组织化学和酶链免疫反应测量脾胃虚寒型、胃热伤阴型胃癌患者及对照组患者活检组织的TM 4个基因(TM1、TM2、TM3、TM4)的表达及其含量。结果脾胃虚寒型胃癌患者TM1的表达明显高于胃热伤阴型,TM2的表达明显低于胃热伤阴型(P<0.01),两型患者TM3、TM4的表达无明显差异(P>0.05)。结论不同证型胃癌患者TM的表达存在差异,TM1、TM2与胃癌证型有一定的相关性。更多还原

【Abstract】 Objective To study the expression of tropomyosin(TM) in different TCM syndromes of terminal gastric cancer to explore the relationship between TM and the TCM syndromes.Methods The 41 cases of terminal gastric cancer with spleen and stomach deficiency-cold syndrome and stomach heat damaging yin syndrome and the 15 cases of chronic superficial gastritis(control group) were selected.The expression and quantity of TM gene(TM1、TM2、TM3、TM4) were tested by immunohistochemistry and ELISA respectively.Results The expression of TM1 in the spleen and stomach deficiency-cold syndrome was higher significantly than that in the stomach heat damaging yin syndrome,and the expression of TM2 was lower significantly than that in the stomach heat damaging yin syndrome,and there was no significantly difference in the expression of TM3 and TM4 between the two syndromes(P>0.05).Conclusion The expression of TM in different TCM syndromes of gastric carcinoma was different.There exists a certain relation in the expression of TM1 and TM2 in different TCM syndromes of gastric cancer.更多还原