【摘要】 目的探讨血甘油三酯及总胆固醇与2型糖尿病合并早期肾病患者的尿微量白蛋白的关系。方法选取86名早期糖尿病肾病患者分为2组:⑴、血脂异常组:共75人,其中甘油三酯>1.70mmol/L的患者59人,总胆固醇>4.8mmol/L的患者59人。⑵血脂正常组:共11人。再将血脂异常组分为3个亚组:A、血甘油三酯异常组(TG组):甘油三酯>1.80mmol/L,总胆固醇<6.0mmol/L,共28名,部分患者合并高低密度脂蛋白胆固醇血症(低密度脂蛋白胆固醇>3.10mmol/L);B、血胆固醇异常组(TC组):甘油三酯<1.80mmol/L,总胆固醇>6.0mmol/L或低密度脂蛋白胆固醇>3.10mmol/L,共17名;C、血甘油三酯和总胆固醇均异常组(TG+TC组):甘油三酯>1.80mmol/L,总胆固醇>6.0mmol/L,共30名,部分患者合并高低密度脂蛋白胆固醇血症(低密度脂蛋白胆固醇>3.10mmol/L)。进行统计学分析。结果①早期糖尿病肾病患者甘油三酯异常的比率明显高于文献报道的2型糖尿病患者甘油三酯异常率。②合并高甘油三酯血症及高低密度脂蛋白胆固醇血症的早期糖尿病肾病患者,尿微量白蛋白明显高于未患上述疾病者。结论2型糖尿病合并早期糖尿病肾病的患者,血脂异常的主要表现为高甘油三酯及高低密度脂蛋白胆固醇血症,早期血脂干预是延缓糖尿病肾病发生的一个重要因素。更多还原

【Abstract】 Objective To explore in the 2-type diabetesmellitus the relationship between abnormal triglyeride(TG)、total cholesterol(TC) and renal damage in patients with diabetic nephropathy(DN).Method Choose 86 patients,all fulfilled the standards below :①W orld Health Organization(WHO) Crite-ria for NIDDM in 1999.② No DM acute complications.③ No infection.④ No renal damage before have DN.⑤ AST、ALT、TBIL、IBIL、DBIL、BUN、CRE,etc is’t pathologic change.According to TG,TC、low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C),patients was divided into 2 groups(1)Dyslipidemia group,included 75 persons(59 persons TG>1.70mmol/L,59 persons TC>4.8mmol/L).⑵N on-dyslipidemia group,including 11 persons.According to TG、TC and LDL-C divided the dyslipidemia group into 3 subgroups:A、TG group:TG>1.80mmol/L,TC< 6.0mmol/L,including 28 persons,some of them LDL-C>3.10mmol/L;B、TC group:TG<1.80mmol/L,TC>6.0mmol/L or LDL-C>3.10mmol/L,including 17 patiens;C、TG+TC group:TG>1.80mmol/L,TC>6.0mmol/L,including 30 persons,some of them LDL-C>3.10mmol/L.There are no significant difference among the 4 groups in DM course、hypertension(systolic pressure and diastolic pressure)、GHbA1C(P>0.05).Result ①The level of TG is evaluated significant in early stage of DN than TG’s level reported in DM.②M AU is evaluated significant when TG or LDL-C evaluated.Conclusion The main abnormal metabolism of serum lipids is elevated of TG and LDL-C in the early stage of DN,therapy dyslipidemia is important for DN.更多还原