【摘要】 目的观察疏血通注射液治疗糖尿病患者下肢动脉硬化闭塞症的有效性和安全性。方法采用随机数字表法将入选的2型糖尿病合并下肢动脉硬化闭塞症患者分为疏血通注射液治疗组(疏血通组)180例和前列地尔治疗对照组(对照组)80例,治疗4周后观察临床疗效,采用多普勒超声检查比较两组治疗前后股浅动脉、胫后动脉及足背动脉的血管内径和血流量。结果疏血通组总有效率为94.4%(170/180),优于对照组85.0%(68/80,P<0.01)。多普勒超声检查,疏血通组治疗后股浅动脉、胫后动脉及足背动脉的血管内径增大、血流量明显增加(P<0.01),并优于对照组(P<0.05)。治疗期间无明显不良反应。结论疏血通注射液有活血化瘀通络的作用,可以减少或消除血栓形成,临床用于糖尿病下肢动脉硬化闭塞症的治疗安全、有效。更多还原

【Abstract】 Objective To observe the effect and safety of Shuxuetong Injection(SXT)in treating patients with type 2 diabetes mellitus accompanying lower extremity atherosclerotic obliterans.MethodsThe selected patients were assigned by randomized digital table to the treated group(180 cases treated with SXT)and the control group(80 cases treated with alprostadil).The clinical efficacy was assessed after 4 weeks of treatment,and the inner diameters and blood flow of the superficial femoral artery,the posterior tibial artery and the foot dorsal artery were measured and compared before and after treatment using Doppler’s ultrasonography.ResultsThe total effective rate in the treated group was 94.4%(170/180),better than that in the control group,85.0%(68/80,P<0.01).Ultrasonic examination showed that the inner diameter and the blood flow of all the arteries measured in the treated groups increased after treatment(P<0.01),with the increase superior to those in the control group(P<0.05).No adverse reaction was found during the treatment.ConclusionSXT has the effect of activating blood circulation,dissolving stasis and dredging collaterals,it could reduce or eliminate the formation of thrombi,being effective and safe when applied in clinical practice for the treatment of lower extremity diabetic atherosclerotic obliterans.更多还原