【摘要】 以纯度为96%的α-桐酸作为对照,考察了从桐油中经NARP-HPLC分离得到的3组含共轭亚麻酸的甘油三酯对人体肿瘤细胞株ECA-109(食管癌)、SGC-7901(胃癌)、Bel-7402(肝癌)、LS-174-T(结肠癌)、KB(口腔癌)和正常细胞株L02(肝细胞)的细胞毒性。结果发现α-桐酸对KB、Bel-7402和SGC-7901细胞的毒性明显弱于3组含共轭亚麻酸的甘油三酯。结果提示,除了α-桐酸的共轭三烯结构是桐油甘油三酯的细胞毒性的物质基础之外,含共轭亚麻酸的甘油三酯的分子结构对其抗肿瘤功效也有重要贡献。更多还原

【Abstract】 The cytotoxic effects of three groups of triacylglycerols containing conjugated linolenic acid which were isolated from tung oil by NARP-HPLC on five human tumor cell lines including ECA-109(esophageal carcinoma),SGC-7901(carcinoma ventriculi),Bel-7402(hepatoma),LS-174-T(colon carcinoma),KB(mouth epidermal carcinoma),and human normal cell line L02(liver cell) were investigated,and α-eleostearic acid with a purity of 96% was used as control.The results showed that α-eleostearic acid showed weaker cytotoxicity than three groups of triacylglycerols for KB,Bel-7402,SGC-7901 cell lines.The cytotoxic effect of α-eleostearic acid and triacylglycerols of tung oil against human tumor cells may be attributable to conjugated trienoic structure.The study suggested that molecular structures of triacylglycerols containing conjugated linolenic acids were important for their cytotoxicity to human tumor cells.更多还原