【摘要】 目的:比较18F-FLT和18F-FDG早期评估荷肺腺癌小鼠放疗疗效。材料和方法:24只T739荷肺腺癌小鼠随机分为18F-FLT和18F-FDG两组,各组再分为对照组和放疗组。放疗组接受20Gy的X线放射治疗后2天,各组小鼠经尾静脉注入18F-FLT和18F-FDG60min后行PET显像并井形探测仪测量活性分布。肿瘤增殖判定采用免疫组织化学方法测定PCNA。结果:放疗后肿瘤18F-FLT摄取较对照组明显降低(0.37±0.12%和1.25±0.19%,P<0.01),而18F-FDG摄取变化不明显。PET显像18F-FLTSUVmax值低于对照组,18F-FDG摄取变化不明显。肿瘤18F-FLT摄取与PCNA指数显著相关(r=0.8805),18F-FDG摄取与PCNA无相关性。结论:放疗后18F-FLT摄取降低较18F-FDG明显,与PCNA指数显著相关,因而18F-FLT是一种监测肿瘤治疗疗效的有前途的示踪剂。更多还原

【Abstract】 Purpose:The aim of this study was to evaluate the additive value of 18F-FLT in monitoring early tumor response to radiotherapy. Materials and Methods:24 mice bearing T739 lung cancer were divided into two groups,one group was treated with irradiation of 20 Gy,and the other group served as control.All mice were given 18F-FLT and 18F-FDG by tail vein in separate PET imaging session. At 60min after tracers injection,biodistribution was assessed with PET imaging. Tumor proliferation was determined by PCNA. Results:In comparison to 18F-FDG,tumoral uptake of 18F-FLT was found more rapidly decreased after radiotherapy(0.37±0.12%vs 1.25±0.19,P<0.01). The tumoral uptake of 18F-FLT correlated well with PCNA labeling index(r=0.8805,P<0.01). Conclusion:The decrease in tumor 18F-FLT uptake after radiotherapy was more pronounced than that of 18F-FDG,suggesting its feasibility in earlier monitoring of radiotherapy.更多还原