【摘要】 目的观察软脉灵口服液治疗血管性痴呆(VaD)的临床疗效及安全性,并探讨其作用机制。方法将60例VaD患者按1∶1比例随机分为两组。治疗组(30例)予软脉灵口服液,每次1支(10mL),每日3次口服,1个月为1个疗程,连服3个疗程;对照组(30例)予以盐酸多奈哌齐(思博海),每次1片(5mg),每日1次临睡前口服,疗程同治疗组。结果总有效率治疗组(96.7%)与对照组(86.7%,)无统计学意义(P>0.05);在简易智能量表(minimentalstateexamination,MMSE)、日常生活功能水平量表(activities of daily living,ADL)积分和实验室指标同型半胱氨酸(Hcy)、血栓素A2(TXA2)、前列环素I2(PGI2)等方面两组比较无统计学意义(P>0.05);在中医证候疗效、临床症状改善、实验室指标内皮素(ET)、TXA2/PGI2等方面,治疗组明显优于对照组(P<0.05)。结论软脉灵口服液为治疗血管性痴呆的有效药物。更多还原

【Abstract】 Objective To observe the clinical curative effect and safety of Ruanmailing oral liquid for vascular dementia (VaD). Methods Sixty patients with VaD were randomized into two groups:Treatment group (n=30) treated with Ruanmailing oral liquid and control group (n=30) treated with donepezil for 3 months.Results The total effective rate in two groups were 96.7% and 86.7% respectively(P>0.05).There were no significant difference in the mini-mental state examination (MMSE),the activity of daily living (ADL) and the levels of homocysteine(Hcy),thromboxane A2(TXA2),prostaglandin I2(PGI2) in two groups(P>0.05).The efficacy of the TCM symptom,improvement of clinical symptoms and endothelins (ET),TXA2/PGI2 in treatment group were better than that control group(P<0.05).Conclusion Ruanmailing oral liquid had good effect in treatment of vascular dementia.更多还原