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夏天无总碱对家兔血液流变性及血小板聚集的影响

Effect of total alkaloids from Rhizoma Corydalis Decumbeutis on blood viscosity and platelet aggregation in rabbits

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【作者】 孟庆玉戴岳林海夏玉凤

【Author】 Meng Qingyu1, Dai Yue2, Lin Hai1, Xia Yufeng2 (1 Hunan Institute of Pharmaceutical Industry Research, Changsha 410014; 2 Department of Pharmacology of China Meteria Medica, China Pharmaceutical University, Nanjing 210038)

【机构】 湖南医药工业研究所中国药科大学中药学院

【摘要】 目的:探讨夏天无总碱对家兔血液流变性及血小板聚集的影响。方法:测定静脉注射夏天无总碱对家兔血黏度和血小板聚集的影响。结果:夏天无总碱0.1,0.2,0.4mg/kg可显著降低家兔全血粘度、红细胞压积和红细胞聚集指数,抑制二磷酸腺苷(ADP)、花生四烯酸(AA)和胶原诱导的家兔血小板聚集。结论:夏天无总碱具有改善家兔血液流变性,抑制血小板聚集的作用。

【Abstract】 Object:To study the effects of total alkaloids from Rhizoma Corydalis Decumbeutis (TARCD) on blood viscosity and platelet aggregation in rabbits. Methods: Blood viscosity and platelet aggregation were measured after intravenous injection of TARCD in rabbits. Results: TARCD significantly reduced plasma and serum viscosity in rabbits, inhibited platelet aggregation induced by ADP, AA and collagen. Conclusion: TARCD possessed the ability of improving blood viscosity and inhibiting platelet aggregation.

  • 【文献出处】 中药药理与临床 ,Pharmacology and Clinics of Chinese Materia Medica , 编辑部邮箱 ,2009年03期
  • 【分类号】R285
  • 【被引频次】13
  • 【下载频次】227
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