【摘要】 目的通过对2008年1月至2009年6月我院临床药学室监测的药物血药浓度结果进行分析,探讨影响药物血药浓度的因素。方法应用TDxFLx血药浓度监测仪监测丙戊酸、环孢素、地高辛等6种常用药物的血药浓度,并讨论测定结果的影响因素和分析测定结果。结果多数丙戊酸、卡马西平的测定结果在有效治疗范围,环孢素影响测定结果的波动大,影响因素较多,个体差异大。结论利用TDxFLx血药浓度监测仪测定药物血药浓度方便、快速且数据准确,能更好为治疗药物检测提供可靠的数据依据。更多还原

【Abstract】 Objective To explore the factors influencing the serum drug concentration through analyzing the monitoring results of serum drug concentration of the samples in the clinical pharmacy from January 2008 to June 2009. Methods The serum drug concentration was assayed by Fluorescence Polarization Immunoassay, then discuss the influencing factors of the results and analyzed the data. Results Most results of valproic acid and carbamazepine were lying in the effective curing range. The serum drug concentration of cyclosporine was irregular. Cyclosporine concentration had more influencing factors and large individual variation. Conclusions The results assayed by Fluorescence Polarization Immunoassay were convenient, quick and accurate. It can provide reliable data for the therapeutic drug monitoring.更多还原