【摘要】 目的探讨早孕期孕妇糖化血红蛋白(GHb)水平与胎儿畸形的关系。方法以来我院早孕门诊孕周小于16w,有糖尿病家族史或糖尿病史的孕妇126例为对象,用高效液相色谱仪(HPLC)测定HbA1 c,孕20~24w进行彩色B超检查。B超未发现异常的胎儿继续妊娠,追踪观察至胎儿娩出,分析HbA1 c水平与胎儿畸形的相关性。结果早孕期HbA1 c水平大于11%时,胎儿畸形发生率明显升高。结论早孕期孕妇糖化血红蛋白水平异常升高与胎儿畸形有密切关系更多还原

【Abstract】 Objective: To evaluate hemoglobin A1c(HbA1c) for predicting congenital abnormalities in overt diabetic pregnancies.Methods:Overt diabetic gravidas with initial hemoglobin A1c(HbA1c) above 6.5%,or a family history of congenital heart disease were referred to detailed fetal sonography and follow-up.Totally,126 patients received care in the diabetes and pregnancy service.Results: An initial HbA1c above 11% was highly associated with fetal abnormalities.Conclusions: Among patients with abnormal HbA1c values,detailed fetal examination was recommended.更多还原