节点文献
131I与抗甲状腺药物治疗甲亢的疗效比较
Therapeutic Effect Comparison of 131I and Anti-thyroid Drugs on Patients with Hyperthyroidism
【摘要】 目的:比较131I与抗甲亢药物(ATD)治疗甲亢的疗效。方法:选择首诊的甲亢患者200例,随机分为两组:131I治疗组与ATD对照组各100例。观察131I与ATD治疗后突眼、甲减及甲亢复发的情况,并观察131I与ATD治疗甲亢并发症的疗效及不良反应。结果:131I与ATD组发生甲减的差异无统计学意义。两组突眼的转归也无差异。131I治疗复发率明显低于ATD组。131I治疗甲亢心脏病疗效优于ATD。131I治疗出现肝损伤、白细胞减少等不良反应低于ATD。结论:131I治疗甲亢是安全有效的,其综合疗效优于抗甲亢药物。
【Abstract】 Objective:To investigate the effects of 131I and anti-thyroid drugs(ATD)on patients with hyperthyroidism.Method: Two hundreds patients with hyperthyroidism were divided into 131I group(100 cases)and ATD group(100 cases).A comparison of curative efficacy,incidence of hypothyroidism,relapse and exophthalmos between two groups were performed.Result:The incidence of hypothyroidism and exophthalmos were no statistical difference between two groups(P>0.05).Compared to ATD group,the incidence of hepatic injury and leukopenia were lower in 131I group(P<0.05).131I was more effective in treatment of hyperthyroid cardiopathy and relapse of hyperthyroidism was lower in 131I group(P<0.05).Conclusion:131I is more effective and safety than anti-thyroid drugs (ATD)in treatment of hyperthyroidism.
【Key words】 Iodine isotopes; Radiotherapy; Propylthiouracil; Methimazole; Hyperthyroidism;
- 【文献出处】 中国药师 ,China Pharmacist , 编辑部邮箱 ,2009年09期
- 【分类号】R581.1
- 【被引频次】7
- 【下载频次】219