【摘要】 目的通过分析瘢痕疙瘩周围部和中央部组织中IGF-I、IGF-IR表达的差异,探讨瘢痕疙瘩呈浸润性生长的机制。方法收集手术切除的瘢痕疙瘩组织8例及周围正常皮肤组织4例,对不同部位的瘢痕疙瘩组织和正常皮肤组织进行免疫组织化学染色,观察各组中IGF-I、IGF-IR的表达,比较瘢痕疙瘩不同部位和正常皮肤组织中IGF-I、IGF-IR表达的差异。结果正常皮肤组织中成纤维细胞中IGF-I、IGF-IR的表达均呈阴性。瘢痕疙瘩周围组织成纤维细胞中IGF-I的表达明显高于中央部,差异有统计学意义(P<0.05);瘢痕疙瘩周围部组织纤维细胞中IGF-IR明显高于中央部,差异有统计学意义(P<0.05)。结论瘢痕疙瘩不同部位IGF-I、IGF-IR的表达差异可能是导致瘢痕疙瘩呈浸润性生长的机制之一。更多还原

【Abstract】 Objective To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin-like growth factor-I(IGF-I)and the insulin-like growth factor-I receptor(IGF-IR)index.Methods Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF-I and IGF-IR.IGF-I and IGF-IR index of difference parts in keloids and normal skin were compared.Results These were no positive fibroblasts in normal skin samples.The IGF-I and IGF-IR index of peripheral parts of keloids are higher than those of central parts,and there is significant difference(P<0.05).Conclusion The difference in distribution of IGF-I and IGF-IR index may be responsible for the aggressive growth of keloid.更多还原