【摘要】 目的探讨不同中医证型多脏器功能障碍综合征(MODS)伴胃肠功能障碍和衰竭(GIDF)患者胃肠激素的临床意义。方法以69例MODS住院患者(热毒证16例,血证8例,气阴两虚证31例,阳气亏虚证14例)为对象,进行MODS和GIDF评分;另取15例体检正常人设为对照组,分别采血检测血清P物质(SP)、血管活性肠肽(VIP)、胃动素(MTL)。结果MTL、VIP、GIDF等在各证型MODS伴GIDF间相近;MODS在血证组时最高,较两种虚证者显著增高,而与热毒证相近;P物质在热毒组最高,其次为气阴两虚证组,再次为血证组,最低为阳气亏虚组。结论MODS伴GIDF患者SP水平随着中医证型的变化而不同。动态观察SP水平可作为MODS伴GIDF辨证的相关参考指标。更多还原

【Abstract】 Objective:To study gastrointestinal hormone in different TCM syndromes of MODS patients with GIDF.Methods:69 MODS patients were scored by MODS and GIDF,which include 16 heat-toxin patients,8 blood syndrome patients,31 deficiency of qi and yin patients and 14 yang deficient patients.Moreover,15 health persons were served as normal control group.Their serum SP,VIP and MTL were measured separately.Results:There were no significant differences in MTL,VIP and GIDF in every syndromes of MODS with GIDF.The MODS in blood syndrome group was the highest.It was higher than another deficiency syndrome groups.However,it approached the level of heat-toxin syndrome.In different syndrome,the SP level was in sequence of the heat-toxin group > the deficiency of qi and yin group > the blood syndrome group >the yang deficiency group.Conclusion:SP levels are altered in patients with different TCM syndromes.Dynamic observation of serum SP level could be contributed to the TCM syndromes differentiations of MODS with GIDF.更多还原