【摘要】 目的:研究开郁清胃颗粒对OLETF胰岛素抵抗大鼠肝及骨骼肌细胞膜胰岛素受体结合率的影响。方法:32周龄雄性OLETF实验大鼠随机分成4组:模型组、罗格列酮组、开郁清胃颗粒大、小剂量组,正常对照组选用同龄Wastar大鼠。各组分别给药4周行正常血糖高胰岛素钳夹实验后检测各项指标。结果:中药小剂量治疗组与糖尿病模型组相比,肝脏及肌肉细胞膜胰岛素受体结合率升高(P<0.01或P<0.05),胰岛素和胰高血糖素水平无明显变化。结论:开郁清胃颗粒可增加肝及骨骼肌细胞膜胰岛素受体结合率。更多还原

【Abstract】 To investigate the effect of Kaiyu-Qingwei-Keli on insulin binding rate of liver and skeletal muscle cell membranes in OLETF rat.Methods:At age of 32 weeks male OLETF rats were randomly divided into four groups,i.e model group,rosiglitazone group,small and big dose Kaiyu-Qingwei-Keli group.The same age Wastar rats were chosed as the normal group.Various items were measured after 4 weeks treatment and englycemic clamp method.Results:Kaiyu-Qingwei-Keli small dose group had higher rate insulin binding of liver and muscle cell membranes(P<0.05 or P<0.01)than that of model group(P<0.001).But the level of insulin and glucagon had not obvious change.Conclusion:The mechanism of KaiyuQingwei-Keli was that it can increased the binding rate of insulin receptor of liver and muscle cell membranes.更多还原