【摘要】 目的:探讨黄白痤疮膏外用治疗寻常痤疮的作用机理。方法:选用成年雄性金黄地鼠侧腹皮脂腺斑作为动物模型,随机分3组分别采用黄白痤疮膏、5%安体舒通乳剂、蒸馏水外擦皮脂腺斑20天,观察皮脂腺斑组织结构及皮脂腺斑的大小变化;应用放射配体结合分析法测定实验地鼠白细胞雄激素受体(AR)含量,放射免疫法检测地鼠血清中睾酮的水平。结果:黄白痤疮膏与安体舒通均能明显缩小金黄地鼠皮脂腺斑,与对照组比较有显著性差异(P(0.01);黄白痤疮膏能明显的改变皮脂腺斑的显微结构,与对照组比较有显著性差异(P(0.05);黄白痤疮膏与安体舒通均具有降低金黄地鼠外周血白细胞AR,与对照组比较有显著性差异(P(0.05)。结论:黄白痤疮膏能抑制皮脂腺细胞的增生和分泌功能,改变皮脂腺斑显微结构,使皮脂腺斑缩小,降低金黄地鼠外周血白细胞AR,对痤疮有良好的防治作用。更多还原

【Abstract】 Objective:To inquire into the function mechanism that Huangbai Acne Ointment utilized a Top-Ical therapy on the ordinary acne.Methods:Adopting golden hamster side stomach gland spot as an animal model,three groups were randomly divided into.They were respectively Huangbai Acne Ointment,5% spironolactone,distilled water for external application on the gland spot of golden hamster side stomach for 20 days,observing the organization of gland spot and the change of gland spot in size;The plasma concentration of AR was determined by Receptor Radio-ligand Banding Assay(RRLBA).Radioimmunoassay measured the level of testosterone in hamster serum.Results:Huangbai Acne Ointment and spironnolatone could contract obviously gland spot of golden hamster,the obvious difference was found(P<0.01),compared with the control group;Huangbai Acne Ointment could change the organization of gland spot the obvious differences was found(P<0.05),compared with the control group;Huangbai Acne Ointment and spironolactone could both lower the androgen of golden hamster AR,the obvious differences was found(P<0.05),compared with the control group.Conclusion:Huangbai Acne Ointment has the function of repressing gland spot’s increase and secrete,changing the organization of gland spot,reducing gland spot,lowering the androgen of golden hamster AR.Above all,Huangbai Acne Ointment has a good prevention and cure function.更多还原