【摘要】 目的调查温州市海洛因依赖者肝功能水平及其影响因素。方法对温州市戒毒所684例海洛因依赖者的ALT、AST等指标进行测定,并与同期在温州市体检中心健康体检的717名正常人群进行比较。结果海洛因依赖者戒毒期ALT和AST水平、肝功能异常率显著高于正常人群(P<0.001),静脉吸毒组的ALT和AST水平、肝功能异常率均显著高于烫吸组(P<0.001);单因素分析显示吸毒时间、每天吸毒剂量与ALT呈正相关(P<0.05),血糖与ALT呈负相关(P<0.001),TG、TC、LDL-C与ALT、AST呈负相关(P<0.05,P<0.001),HDL-C与ALT、AST呈正相关(P<0.05);多因素非条件Logistic回归分析显示ALT异常与吸毒时间、吸毒方式、血糖有关,AST异常与吸毒方式、血脂有关。结论温州市海洛因依赖者转氨酶水平、肝功能异常患病率均显著高于正常人群,可能与长时间吸毒、静脉吸毒方式、低血糖、低甘油三酯等有关。更多还原

【Abstract】 Objective To survey the liver function level and the risk factors in heroin addicts in Wenzhou city. Methods A total of 684 heroin addicts in Drug Rehabilitation Center of Wenzhou city and 717 health persons in Medical Examination Center of Wenzhou city were surveyed contemporaneously. The levels of ALT,AST were measured and compared in both of heroin addicts and healthy cases. Results Comparing with healthy cases,ALT and AST levels,abnormal rate of liver function in heroin addicts were significantly higher during withdrawal period (P<0.001). Likewise,ALT and AST levels,abnormal rate of liver function were higher in intravenous drug users than in inhaling drug users. Both of the drug-using time and the daily dose had positive correlation with ALT level in heroin addicts (P<0.05). The relationship between blood glucose and ALT level was negative (P<0.001). TG,TC and LDL-C had a negative correlation with ALT level (P<0.05) and AST level (P<0.001),respectively. And the relationship between HDL-C and ALT level and AST level was positive (P<0.05). Logistic Regression analysis indicated that drug-using time,intravenous injection and blood glucose were associated with ALT abnormality,while intravenous injection and TG were associated with AST abnormality. Conclusion The transaminase levels and prevalence rates of liver function abnormality were significantly higher in heroin addicts than in normal persons. It may be associated with the long drug-using time,intravenous injection,low BG and low TG.更多还原