【摘要】 目的:评价家兔经口给药槐果碱和槐定碱的药动学。方法:建立反相高效液相色谱法,评价家兔经口给药槐果碱和槐定碱的药动学。结果:家兔经口给药槐果碱和槐定碱后,体内过程都符合二室、一级吸收、有滞后时间模型,模型权重为1/C/C。槐果碱的分布和消除速度都比槐定碱快。结论:家兔空腹单次经口给药槐果碱和槐定碱后,槐果碱的AUC低于槐定碱;槐果碱的分布和消除速度都比槐定碱快。更多还原

【Abstract】 Objective: To evaluate the pharmacokinetic properties of single dose of sophocarpine and sophoridine in rabbit.Methods: RP-HPLC method was used for determining sophocarpine and sophoridine in rabbit plasma,and the pharmacokinetic parameters following oral administration were calculated.Results: The plasma drug concentration-time curve after oral administration of a dose of 200mg·kg-1 sophocarpine or sophoridine fitted to a two-compartmant model,first order absorption,lag time model with weights of 1/C/C in rabbits.The absorption and elimination rates of sophocarpine were faster than those of sophoridine.Conclusion: Following oral administration in rabbits,the AUC for sophocarpine was lower than that for sophoridine,and the absorption and elimination rates of sophocarpine were faster than those of sophoridine.更多还原