【摘要】 目的:评价盐酸戊乙奎醚对离体大鼠子宫收缩的影响。方法:采用乙酰胆碱(Ach)致大鼠离体子宫痉挛模型,测量给予盐酸戊乙奎醚后大鼠离体子宫条痉挛收缩的最大张力,用经典的Schild方法计算受试药的pA2值。实验同时使用非选择性胆碱受体阻滞剂阿托品和选择性M2受体阻滞剂加那胺(gallam ine)作阳性对照药。结果:盐酸戊乙奎醚的pA2值显著大于硫酸阿托品pA2值[(12.19±1.10)vs(9.36±2.30),P<0.05],与加那胺的pA2值接近(12.49±2.20)。盐酸戊乙奎醚对离体大鼠子宫抗Ach痉挛的松弛作用强度明显大于硫酸阿托品。结论:盐酸戊乙奎醚能有效地缓解离体大鼠子宫的痉挛状态。更多还原

【Abstract】 Objective:To investigate the effect of penehyclidine hydrochloride(PHC) on contraction in rat uterus.Methods: The contraction of isolated rat uterus was induced by acetylcholine.The maximum amplitude of contractions was measured after exposure to PHC,atropine(a non-selective M receptor antagonist) and gallamine(an M2 receptor antagonist).The pA2 value was determined by Schild assay.Results: According to pA2 values,the antagonizing effect of PHC on acetylcholine-induced contraction in isolated rat uterus was stronger than that of atropine [(12.19±1.10) vs(9.36±2.30),P<0.05],and was similar to that of gallamine(12.49±2.20).Conclusion: PHC can effectively relieve uterus contraction in vitro.更多还原