【摘要】 目的探讨胃肠道间质瘤(GIST)的临床病理、免疫组化特点及危险度参考指标,分析其在临床预后评估中的价值。方法观察39例GIST的病理形态特征,完成肿瘤性质初步判定,采用免疫组化方法检测分析CD117、CD34、SMA及S-100的表达水平,最终确定GIST的临床病理诊断性质、特征、组织来源以及良恶性。结果免疫组化染色显示CD117呈弥漫强阳性,CD34多呈弥漫强阳性,SMA及S-100偶呈局灶或散在阳性,阳性率分别为100%、81%、20%和16%。确诊该组39例GIST,其中可能良性5例,潜在恶性10例,恶性24例。结论免疫组化测定是GIST病理诊断的重要依据,CD117是诊断GIST的敏感而特异性的标志物。肿瘤病理判定与患者预后密切相关。更多还原

【Abstract】 Objective To explore the criteria of pathologic diagnosis for gastrointestinal stromal tumors(GIST)and the reference parameters for malignancy,and to evaluate the clinical prognosis.Methods The expression levels of CD117,CD34,SMA and S-100 were detected by immunohistochemical method and their morphologic characteristics were analyzed by Light microscopy.Results The immunohistochemical results showed that CD117 were diffusely strongly expressed in all of GIST;CD34 also diffusely strongly in most of GIST;SMA and S-100 incidentally in some focus.Their positive rates were 100%,81%,20% and 16% respectively.5 benign cases,10 potential malignancy cases and 24 malignant cases were finally diagnosed.Conclusion The pathologic diagnosis of GIST should be made based on the immunohistochemical staining results.CD117 was a sensitive and specific marker for diagnosing GIST.The prognosis was closely related to the degree of pathologic malignancy.更多还原