【摘要】 目的观察复方苦参结肠溶胶囊对溃疡性结肠炎(UC)患者(湿热内蕴证)结肠黏膜IκB-α蛋白表达的作用,并对其作用机制进行初步探讨。方法经结肠镜及病理证实的24例UC患者,随机分为中药组(16例)和西药组(8例),中药组用复方苦参结肠溶胶囊治疗,西药组用美沙拉嗪治疗,共治疗8周。采用免疫组化法检测两组治疗前后IκB-α蛋白的阳性细胞表达率。结果治疗前全部结肠黏膜IκB-α蛋白阳性细胞表达率明显高于治疗后(P<0.01),治疗后复方苦参结肠溶胶囊组结肠黏膜IκB-α蛋白阳性细胞表达率与西药组差异无统计学意义(P>0.05)。结论复方苦参结肠溶胶囊组使UC患者结肠黏膜IκB-α蛋白阳性细胞表达率明显降低,这可能是其治疗UC的作用机制之一。更多还原

【Abstract】 Objective To study the effect of compound recipe lightyellow sophora root caps(LSRC)on the expression of IκB-α in colonic mucosa of patients with ulcerative colitis(damp-heat brewing internally),and to explore the therapeutic mechanism.Methods 24 patients with ulcerative colitis who were diagnosed by colonoscope and biopsy were randomly divided into two groups as follows:the TCM group and the western medicine group.16 patients in the TCM group were treated with LSRC for 8 weeks,and 8 patients in the western medicine group were treated with mesalazine for 8 weeks.The positive expression rate of IκB-α was measured by immunohistochemical method.Results The positive expression rate of IκB-α in two groups decreased significantly after treatment(P<0.01),but the difference between two groups was no significant(P>0.05).Conclusion One of the therapeutic mechanism of LSRC may attribute to its inhibiting the positive rate of IκB-α in colonic mucosa of patients with ulcerative colitis.更多还原