【摘要】 [目的]观察柴枳朴槟汤对吗啡所致胃肠功能障碍小鼠的影响。[方法]取小鼠70只,随机分成正常组,模型组,西沙比利组,番泻叶组和柴枳朴槟汤低、中、高剂量(低、中、高剂量)组,每组10只。正常组每天皮下注射0.85%氯化钠0.15 ml/(只.d),其余各组小鼠每天皮下注射吗啡注射液(1 mg/ml)0.15 ml/(只.d)的基础上加用不同的药物灌胃,模型组予以0.85%氯化钠0.2 ml/(只.d),西沙比利组予以2%西沙比利0.2 ml/(只.d),高、中、低剂量组分别予以不同浓度(20.8、10.45、.2 g/ml)的柴枳朴槟汤0.2 ml,共喂药10 d,观察各组小鼠胃排空、小肠推进率、全肠道通过时间及6 h内粪便量。[结果]胃排空实验:西沙比利组、高剂量组与模型组比较,差异有统计学意义(P<0.05)。小肠推进实验:番泻叶组、中剂量组与模型组比较,西沙比利组与高剂量组比较,差异均有统计学意义(P<0.05,<0.01)。全肠道通过时间的测定:番泻叶组、高剂量组、西沙比利组与模型组比较,差异均有统计学意义(P<0.05,<0.01)。6 h内粪便量的测定:中剂量组及西沙比利组、番泻叶组、高剂量组与模型组比较,差异均有统计学意义(P<0.05,<0.01)。[结论]柴枳朴槟汤可促进吗啡所致胃肠功能障碍小鼠的胃排空和小肠推进,缩短粪便排出时间,增加排出量,不影响吗啡的镇痛作用。更多还原

【Abstract】 [Objective]To study the mechanism effects of Chaizhi Pobing Recipe(CZPBR)on morphine-induced gastrointestinal motility disorder mice.[Methods]Seventy mice were divided into seven groups randomly:group A was treated with morphine and isotonic Na chloride,group B was treated with morphine,group C was treated with morphine and Cisapride,group D was treated with morphine and Fanxieye.Group E/F/G were treated with morphine and CZPBR of different disoage.A series of experiments of gastrointestinal tract movement were observed after 10 days.[Results]CZPBD can increase the intestinal accentuation and medicamentosus diarrhea of mice.[Conclusion]CZPBD can improve the gastrointestinal motility disorder-induced by morphine in mice.更多还原