【摘要】 目的:观察肝脾调补合剂对血吸虫病肝纤维化小鼠的影响。方法:将30只昆明小鼠随机分为健康组、对照组与治疗组,采用日本血吸虫尾蚴攻击感染对照组和治疗组小鼠,16周后建立血吸虫病肝纤维化模型,治疗组小鼠用肝脾调补合剂灌胃(1ml/d)和硫普罗宁0.1g皮下注射;对照组小鼠单用硫普罗宁,均连续10周。观察小鼠肝肉芽肿改变,肝纤维化指标HA、LN、PⅢP和Ⅳ-C的变化。结果:治疗组小鼠治疗后肝纤维化指标明显好转,虫卵肉芽肿明显变小,与对照组相比,差异均有显著性意义(P<0.05),治疗组小鼠肝纤维化指标HA、LN、PⅢP和Ⅳ-C均有明显下降,与对照组比较,差异有显著性意义(P<0.05)。结论:肝脾调补合剂与硫普罗宁联合应用能使血吸虫病肝纤维化小鼠肝纤维化指标下降,肉芽肿变小,能明显减轻肝纤维化程度。更多还原

【Abstract】 Objective:To study the curative effect of Ganpitiaobu decoction in mice with schistosomal liver fibrosis.Methods:Thirty Kuming mouse were randomly divided into health group,control group and experimental treatment group.The mouse in the control group and the experimental treatment group were infected by cercariae of schistosoma japonicum.The models of schistosome hepatic fibrosis were established after 16 weeks.Every mouse in the experimental treatment group was feeded with Ganpitiaobu decoction at 1 ml/day and injected with tiopronin at 0.1g/day by subcutaneous injection.The mouse in the control group were only injected with tiopronin.The changes of the granulomas and the parameters of liver fibrosis were obseved,such as HA,LN,PⅢP and Ⅳ-C after 10 weeks. Results: After treatment,the parameters of liver fibrosis in the experimental treatment group were improved more obviously,and ther granulomas were also smaller than those of the control group(P<0.05).Conclusion:The treatment of Ganpitiaobu decoction combined with tiopronin can lower the parameters of liver fibrosis,lessen the granulomas and improve liver fibrosis.更多还原