【摘要】 目的研究广西扶绥地区壮族和汉族人群DNA修复基因XRCC1Arg280His多态性与肝细胞癌(HCC)遗传易感性的相关性。方法采用病例-对照研究方法,对当地壮族和汉族各50例肝癌患者和30例健康人群,应用PCR-RFLP的方法检测Arg280His基因型频率和等位基因频率,并比较两个民族不同基因型与HCC易感性的关系。结果通过XRCC1 Arg280His多态基因型检测分型发现,在壮族和汉族人群中,病例组携带变异等位基因His的频率分别为11%和13%,对照组分别为10.0%和11.7%,等位基因在两组间分布均差异没有显著性(P>0.05)。基因型分布符合Hardy-Weinberg平衡定律,且在2组间差异均无显著性(P>0.05)。结论广西扶绥人群中,XRCC1 Arg280His基因多态性与HCC风险不存在显著相关性。更多还原

【Abstract】 【Objective】To study the correlations of DNA repair gene XRCC1 Arg280His polymorphism and genetic susceptibility to hepatocellular carcinoma (HCC) between the population of Zhuang and Han Nationality in Fusui County of Guangxi.【Methods】Case-Control study were adopted for 50 patients with HCC and 30 health controls in local high-risk region, Arg280His genotypes frequencies and allelic frequencies were analyzed by PCR- RFLP and sequencing.【Results】Compared between the population of Zhuang and Han Nationality, the frequencies of mutant 280His alleles were 11% and 13% in the case group, respectively, and 10% and 11.7% in the controls group; there was no significant difference between the 2 groups (P >0.05).All the polymorphic genotypes distribution met the Hardy-Weinberg equilibrium. 【Conclusion】There is no obvious correlation for XRCC1 Arg280His polymorphism and HCC between Zhuang and Han Nationality in Fusui.更多还原