【摘要】 目的探讨C-反应蛋白(C-reactive protein,CRP)、P-选择素(P-selectin,Ps)、白细胞介素-6(interleukin-6,IL-6)等炎症标志物与急性冠脉综合征(acute coronary syndrome,ACS)的关系。方法测定126名冠心病患者入院及出院时血中CRP、Ps、IL-6浓度,分析它们与ACS患者病情、冠脉病变程度的关系并观察心脏事件的发生率。结果ACS患者CRP、Ps、IL-6浓度较对照组明显增高(P<0.01),并随病情严重程度增加而增高(急性心肌梗死>不稳定性心绞痛>稳定性心绞痛,P<0.05),也随病变冠脉数量的增加而增高(三支病变组>二支病变组>单支病变组,P<0.05);住院及随访期间发生心脏事件与未发生患者组之间CRP、Ps、IL-6浓度比较,差异均有统计学意义(P<0.01)。结论炎症反应与ACS的发生、发展有关,监测血中CRP、Ps、IL-6等炎症标志物的水平对判断ACS诊断、临床预后评估及中、近期心脏事件发生有较高的预测价值。更多还原

【Abstract】 【Objective】To study of the relativity between C-reactive protein(CRP),P-selectin(Ps),interleukin-6(IL-6) and acute coronary syndrome(ACS).【Methods】The serum CRP,Ps,IL-6 and progression of coronary artery in 126 patients with ACS at hospitalization and discharging were measured,their rate of major adverse cardiac events(MACE) were observed.【Result】The levels of serum CRP,Ps,IL-6 in patients with ACS were significantly higher than normal controls(P <0.01),the severer the disease,the higher the levels(stable angina pectoris < unstable angina pectoris < acute myocardial infarction).They also increased with the increasing extent of the numbers of diseased coronary vessels(the 3-vessel-disease group > the 2-vessel-disease group > the 1-vessel-disease group,P <0.05),Among them,the levels of serum CRP,Ps and IL-6 in patients with cardiac events were significantly higher than others were in hospital and in following 12 months(P <0.01).【Conclusion】Inflammatory reaction was closely associated with ACS,monitoring the levels of CRP,Ps and IL-6 are important to diagnosis,treatment,prognosis and anticipant value for shot and long-term cardiac events.更多还原