【摘要】 目的检测肿瘤坏死因子α(TNFα)和肿瘤坏死因子受体1(TNFR1)在子宫腺肌病(腺肌病)组织中的表达,探讨其发病机制。方法采用免疫组化SABC法检测40例腺肌病患者在位及异位子宫内膜组织TNFα和TNFR1的表达,并与20例正常子宫内膜进行比较。结果TNFα在腺肌病组在位、异位及对照组内膜中的表达差异均无显著性(P>0.05);而TNFR1除在腺肌病组异位内膜显著低于对照组外(P<0.05),余组间差异均无显著性(P>0.05)。腺肌病组在位内膜增生期与分泌期TNFα的表达差异无显著性(P>0.05),而TNFR1的表达分泌期显著高于增生期(P<0.05);腺肌病组异位内膜增生期与分泌期TNFα、TNFR1的表达差异均无显著性(P>0.05);而在对照组两者的表达均分泌期明显高于增生期(P<0.05)。TNFα在腺肌病组在位内膜增生期的表达显著高于对照组同期(P<0.05);TNFR1在分泌期的表达为腺肌病组异位内膜<腺肌病在位内膜<对照组,两两比较差异均具有显著性(P<0.05)。结论TNFα、TNFR1参与正常子宫内膜的周期性调节。在位内膜分泌期及异位组织中TNFR1的低表达可能与腺肌病的发生发展有关。更多还原

【Abstract】 【Objective】 To detect the expression of TNFa and TNFR1 in adenomyosis,so as to investigate the pathogenesis of the adenomyosis.【Methods】Immunohistochemical Strept Avidin Biotin Complex(SABC) methods was used to detect the expression of the TNFa and TNFR1 in eutopic and ectopic endometrium of the 40 cases ade-nomyosis,and compare with 20 control cases.【Results】The expression of TNFa has no significant defference in the eutopic and ectopic endometrium of adenomyosis and the control group(P >0.05),but the expression of TNFR1 has a significant defference except between ectopic endometrium of the adenomyosis and controls(P <0.05),the others have no significant defference(P >0.05).The expression of TNFa has no significant defference between the proliferative and secretory phase in eutopic endometrium of adenomyosis(P >0.05),but the TNFR1 has significant defference which in the secretory is higher than in proliferative phase(P <0.05).The expressions of TNFa and TNFR1 have no significant defference between the prolifective and secrective phase in the ectopic endometrium of adenomyosis(P > 0.05),but they are both higher in the secretive phase than in proliferative phase in the control group(P <0.05).The expression of TNFa is higher in the proliferatical phase of ectopic endometrium of adenomyosis than the same phase of the control cases(P <0.05).The expression of TNFR1 is lower in secretive phase in ectopic endometrium of adeno-myosis than its eutopic endometrium and the control cases(P <0.05).【Conclusions】The TNFa and TNFR1 take part in the adjustment of normal menstruation circle.The lower expression of TNFR1 in secrective phase in eutopic en-dometrium and in ectopic endometrium may play a crucial role in the pathogenesis of the adenomyosis.更多还原