【摘要】 目的观察辛伐他汀对原发性高血压患者血清细胞因子肿瘤坏死因子(TNF-α)和白细胞介素-6(IL-6)水平的影响。方法94例原发性高血压患者随机分为辛伐他汀试验组48例,对照组46例,试验组服用辛伐他汀10mg/d4周,分别于服药前后采用放射免疫分析法测定2组患者血清细胞因子TNF-α、IL-6活性水平。结果试验前,试验组和对照组的血清TNF-α、IL-6水平之间比较差异无显著性(P>0.05)。治疗4周后,试验组血清TNF-α、IL-6水平明显比对照组的血清TNF-α浓度低(P<0.05)。结论辛伐他汀通过抑制原发性高血压患者血清细胞因子TNF-α和IL-6的产生,干预原发性高血压的病理生理过程。更多还原

【Abstract】 【Objective】To investigate the effects of Simvastatin on serum TNF-α and IL-6 levels in patients with essential hypertension.【Methods】Ninety-four patients with essential hypertension were randomly divided into Simvastatin group(n =48,10 mg daily for 4 weeks) and control group(n=46). The serum TNF-α and IL-6 levels were detected by radioimmunoassay before and after simvastatin treatment.【Results】Before Simvastatin treatment,there was no significant difference in both TNF-α and IL-6 serum levels(P >0.05). However,the serum TNF-α and IL-6 levels in Simvastatin group were lower than those in control group(P <0.05) after 4 weeks.【Conclusion】Simvastatin decrease serum TNF-α and IL-6 levels in patients with essential hypertention,which suggests Simvastatin might be beneficial to patients with essential hypertension.更多还原