【摘要】 目的该实验研究不同浓度的rhNK4因子对多种肿瘤细胞生长侵袭能力的影响。方法通过基底膜侵袭实验检测并分析基因重组NK4对人宫颈癌、乳腺癌、卵巢癌等肿瘤细胞体外的抑瘤侵袭性。结果实验证明rhNK4因子对人卵巢癌、宫颈癌、乳腺癌细胞有明显的抑瘤侵袭性,对人卵巢癌细胞、宫颈癌细胞、人乳腺癌细胞和人膀胱癌细胞的抑制率分别为48.2%,29.6%,,58.4%和30.1%。结论基因重组NK4因子具有抑制人宫颈癌、乳腺癌等多种肿瘤细胞侵袭的能力,有较强的抑瘤侵袭性。更多还原

【Abstract】 【Objective】To study the effect of rhNK4 at different concentrations on invasion of multiple tumor cells.【Methods】The invasive capacity of human ophoroma cells,human cervical cancer cells,breast cancer cells,and human bladder cancer cells was evaluated by reconstituted basement membrane invasion assay.【Results】 rhNK4 factor suppressed human oophoroma cells,human cervical cancer cells,breast cancer cells,and human blad-der cancer cells that invaded the reconstituted basement membrane by 48.2%,29.6%,58.4% and 30.1%.【Conclu-sion】rhNK4 factor can inhibit the invasion of multiple tumor cells.更多还原