【摘要】 目的:主要探讨短期胰岛素强化治疗对2型糖尿病磺脲类继发失效患者β细胞分泌功能的影响。方法:2型糖尿病磺脲类继发失效患者31例。停用原口服药后予以胰岛素强化治疗,疗程2周。通过检测治疗前后糖代谢参数,计算β细胞分泌功能和胰岛素抵抗状况等。结果:胰岛素强化治疗后血糖达标时间为(4.4±2.1)d,胰岛素剂量平均为(48.6±19.2)U/d,未出现显著不良反应。与治疗前比较,治疗后β细胞分泌功能和胰岛素抵抗均显著改善(P<0.01)。结论:短期胰岛素强化治疗,可改善2型糖尿病磺脲类继发性失效患者的β细胞分泌功能和胰岛素抵抗。更多还原

【Abstract】 Objective:To evaluate the effect of short-term intensive insulin therapy on β cell secretion function and insulin resistance in secondary failure of sulfonylurea of patients with T2DM.Methods:31 patients with secondary failure of sulfonylurea were enrolled.All oral anti-diabetic agents were discontinued and intensive insulin regimens were given by insulin pump or multiple subcutaneous infusion for 2 weeks.Beta-cell secretion function and insulin resistance were evaluated by OGTT and insulin releases test before and after the treatment.Results:After the treatment,blood-glucose control average time was(4.4±2.1) d,and insulin average dose was(48.6±19.2) U/d.Adverse reactions were slight.Compared to before the treatment,there was a significant improvement in beta-cell secretion function and insulin resistance status(P<0.01).Conclusion:The short term intensive insulin therapy can improve Beta-cell secretion function and insulin resistance in patients with secondary failure of sulfonylurea.更多还原