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还原型谷胱甘肽(古拉定)治疗急性脑梗死的临床研究

Therapeutic Effect of Reducing Glutathione on Acute Cerebral Infarction

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【作者】 黄开梅赵中陈伟贤高炳忠周沁邱晨红

【Author】 HUANG Kai-Mei,ZHAO Zhong,CHEN Wei-Xian,et al.(Department of Neurology,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215001,China)

【机构】 南京医科大学附属苏州医院神经内科南京医科大学第一附属医院神经内科

【摘要】 目的:观察古拉定治疗急性脑梗死(ACI)的疗效。方法:选择ACI患者82例,随机分为治疗组和对照组,对照组给予常规治疗,治疗组加用古拉定。观察两组治疗前后神经功能缺损程度评分(neurologic function deficit score,NDS)及血清心型脂肪酸结合蛋白(Heart Fatty acid binding protein,H-FABP)的浓度变化。结果:两组治疗后临床疗效及NDS较治疗前均有明显改善(P<0.01),古拉定组改善程度与对照组相比差异有统计学意义(P<0.01),古拉定组在治疗后第7天及第14天降低血清中H-FABP的浓度较对照组更明显(P<0.05)。结论:古拉定治疗急性脑梗死疗效显著。

【Abstract】 Objective:To investigate the therapeutic effect of Reducing Glutathione on acute cerebral infarction.Methods:82 cases of acute cerebral infarction were divided into two groups randomly.Regular treatment(regular group)and regular treatment plus Reducing Glutathione.The neurological deficit scores(NDS),H-FABP were evaluated.Results:After treatment,neurologic function deficit score(NDS) of two groups after treatment were significantly lower than those of before treatment(P<0.01),Reducing Glutathione group improvement were obviously better than those in the control group(P<0.01).Serum H-FABP concentrations in 7th、14thday in gulading group were lower than that regular group(P<0.05).Conclusion:The therapeutic effect of reducing glutathione on acute cerebral infarction is obvious.

【基金】 江苏省苏州市科技局社会发展项目(编号:SZD0795)
  • 【文献出处】 中国误诊学杂志 ,Chinese Journal of Misdiagnostics , 编辑部邮箱 ,2009年13期
  • 【分类号】R743.33
  • 【下载频次】72
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