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还原型谷胱甘肽(古拉定)治疗急性脑梗死的临床研究
Therapeutic Effect of Reducing Glutathione on Acute Cerebral Infarction
【摘要】 目的:观察古拉定治疗急性脑梗死(ACI)的疗效。方法:选择ACI患者82例,随机分为治疗组和对照组,对照组给予常规治疗,治疗组加用古拉定。观察两组治疗前后神经功能缺损程度评分(neurologic function deficit score,NDS)及血清心型脂肪酸结合蛋白(Heart Fatty acid binding protein,H-FABP)的浓度变化。结果:两组治疗后临床疗效及NDS较治疗前均有明显改善(P<0.01),古拉定组改善程度与对照组相比差异有统计学意义(P<0.01),古拉定组在治疗后第7天及第14天降低血清中H-FABP的浓度较对照组更明显(P<0.05)。结论:古拉定治疗急性脑梗死疗效显著。
【Abstract】 Objective:To investigate the therapeutic effect of Reducing Glutathione on acute cerebral infarction.Methods:82 cases of acute cerebral infarction were divided into two groups randomly.Regular treatment(regular group)and regular treatment plus Reducing Glutathione.The neurological deficit scores(NDS),H-FABP were evaluated.Results:After treatment,neurologic function deficit score(NDS) of two groups after treatment were significantly lower than those of before treatment(P<0.01),Reducing Glutathione group improvement were obviously better than those in the control group(P<0.01).Serum H-FABP concentrations in 7th、14thday in gulading group were lower than that regular group(P<0.05).Conclusion:The therapeutic effect of reducing glutathione on acute cerebral infarction is obvious.
【Key words】 Brain Infarction/drug therapy; Glutathione/therapeutic use; Acute Disease; Treatment Outcome; Randomized Controlled Trial[Publication Type]; Humans;
- 【文献出处】 中国误诊学杂志 ,Chinese Journal of Misdiagnostics , 编辑部邮箱 ,2009年13期
- 【分类号】R743.33
- 【下载频次】72