【摘要】 目的探讨细胞因子sIL-2R在异基因造血干细胞移植(allo-HSCT)后急性移植物抗宿主病(aGVHD)发病机理中的作用。方法观察20例Allo-HSCT患者aGVHD的发病情况,移植前后定期采集20例患者的外周血,采用双夹心酶联免疫吸附法(ELISA)检测其细胞因子sIL-2R的浓度。结果①异基因造血干细胞移植后20例患者全部获得造血功能重建,中性粒细胞恢复到0.5×109/L及血小板恢复到20×109/L的中位时间分别为移植后13.5d及18d;②发生aGVHD的患者,sIL-2R浓度较移植前明显升高,sIL-2R浓度在aGVHD阳性组明显高于aGVHD阴性组(P<0.01)。结论①细胞因子sIL-2R在aGVHD的发病中起重要的正向调节作用,检测异基因造血干细胞移植后患者血清的sIL-2R水平有助于预测aGVHD的发生;②sIL-2R与感染无相关性。更多还原

【Abstract】 Objective To study the effect of cytokine sIL-2R on acute graft-versus-host disease(aGVHD) after allogeneic hemopoietic stem cell transplantation(allo-HSCT).Methods The aGVHD was observed in 20 patients with Allo-HSCT.The peripheral blood of 20 patients was collected before and after transplantion,the concentration of sIL-2R was detected by enzyme-linked immunosorbentassay(ELISA).Results The haematogenesis of 20 patients recovered after the allogeneic hemopoietic stem cell transplantation.The median-time that neutrophilic granulocyte recovered to 0.5×109/L was 13.5 days,the median-time that platelet recovered to 20×109/L was 18 days.The concentration of sIL-2R in patients with aGVHD significantly increased more than that in patients without aGVHD(P<0.01),Conclusions sIL-2R has the up-regulated function in Agvhd.It’s valuable to detect the concentration of sIL-2R after transplantation for predicting aGVHD.更多还原