【摘要】 目的了解我院药品不良反应(ADR)的发生情况,为临床合理用药提供依据。方法收集我院2007～2008年间上报的178例ADR报表,将患者性别、年龄、给药途径、所涉及的药品种类、临床表现、报告人群等进行统计分析。结果两年中均以静脉滴注所引起的ADR所占的比例最高(分别为72.29%和72.92%)。引起ADR比例最高的为抗菌药物(分别为31.40%和43.30%);所累及的器官或系统两年均以消化系统损害占首位(分别为26.67%和27.27%),2007年皮肤及附件损害位居第二位(23.33%)。2008年用药部位损害跃居第二位(22.73%),中枢神经系统不良反应仍居第三位。医师提交的报告较多(分别为74.39%和54.17%)。结论应重视ADR监测工作,更好地保障患者用药安全。更多还原

【Abstract】 Objective To investigate the incidence of adverse drug reactions(ADR)occurred in our hospital for reference of clinical rational drug administration.Methods 178 ADR cases reported in our hospital between 2007 and 2008 were analyzed statistically in respect of patients’ sex,age,routes of administration,variety of drugs and clinical manifestations,etc.Results The ratio of the ADR induced by intravenously administered drugs(72.29% and 72.92% in 2007 and 2008,respectively)was the highest.Antibacterials were the major causes of ADR(31.40 % and 43.30% in 2007 and 2008,respectively).Gastrointestinal lesion was the most common ADR in 2007 and 2008(26.67%和27.27%,respectively).Lesion of skin and its accessories dominated the second place in 2007(23.33%).In 2008,the lesion at the portion of administration dominated the second place(22.73%).The ADR reports from doctors(74.39% and 54.17% in 2007 and 2008,inspectively)were more than those from nurses and pharmacists.Conclusion ADR monitoring should be emphasized in order to ensure clinical rational drug administration and the patients’ safety.更多还原