【摘要】 目的探讨低温射频消融术(temperature-controlled radiofrequency ablation,TCRF)对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者近期生活质量的改善情况。方法对经多导睡眠监测仪(polysomnography,PSG)确诊的70例OSAHS采用TCRF治疗,比较手术治疗前后Epworth嗜睡评分(Epworth sleepiness scale,ESS)和Calgary生活质量指数(Calgary sleep apnea quality of life index,SAQLI)并分析其相关性,从生活质量方面对TCRF治疗OSAHS进行疗效评价。结果术前ESS评分与BMI、AHI、LSaO2、SAQLI总分相关,相关系数分别为0.410、0.371、-0.441、-0.411,P值均<0.01。SAQLI术前总分与年龄、ESS术前评分相关,相关系数分别为0.232、-0.411,P值均<0.01。术后ESS评分及SAQLI总分与术后AHI、LSaO2均无相关性。术后6个月复查,ESS评分(3.8±3.0)分显著低于术前(9.3±4.9)分(t=-17.546,P=0.000),SAQLI总分(4.5±1.2)分显著高于术前(3.8±1.2)分(t=13.132,P=0.000),与术前比较差异均具有统计学意义。结论TCRF可提高OSAHS患者的近期生活质量,对TCRF治疗OSAHS的疗效评价宜结合主、客观指标。更多还原

【Abstract】 Objective To investigate the short-term improvement of life quality in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)after temperature-controlled radiofrequency ablation(TCFR).Methods Totally 70 patients with OSAHS were diagnosed by polysomnography(PSG)and received TCRF in our department.The Epworth Sleepiness Scale(ESS)and Calgary Sleep Apnea Quality of Life Index(SAQLI)were surveyed before and after the therapy.The results were followed up for six months after the operation.Results The pre-operative scores of ESS was correlated with body mass index(BMI),apnea hypopnea index(AHI),lowest saturation(LSaO2)and the scores of SAQLI(correlation coefficient:0.410,0.371,-0.441,and-0.411 respectively;all P<0.01).Preoperative scores of SAQLI was correlated with age and scores of ESS(correlation coefficient:0.232 and-0.411,respectively,both P<0.01).No correlation between EES or SAQLI scores and AHI or LSaO2 after the operation.At six months after the operation,EES decreased significantly compare to preoperation(3.8 ±3.0 vs 9.3±4.9,t=-17.546,P=0.000),whereas,the scores of SAQLI increased from 3.8±1.2 to 4.5±1.2(t=13.132,P=0.000).Conclusions TCFR is an effective treatment for improving life quality of patients with OSAHS.However,there are no correlations between the scores of ESS and AHI,LSaO2,nor between the scores of SAQLI and AHI,LSaO2 after the operations.Both subjective and objective indices are necessary in the evaluation of its therapeutic effect.更多还原