【摘要】 目的:探讨血浆同型半胱氨酸(Hcy)检测在肝硬化及肝癌患者中的临床价值和肝硬化患者随访2年后血浆Hcy含量的变化。方法:检测137例肝硬化患者、43例肝癌患者和50例对照组的血浆Hcy水平,肝硬化患者随访2年后再次检测血浆Hcy含量,对检测结果进行统计分析。结果:肝硬化及肝癌组Hcy水平明显升高,具有统计学意义(P<0.05或P<0.01),肝硬化患者随着Child-Pugh分级的升高而递增,而且肝癌组与肝硬化各级之间比较,A级、B级差异非常显著(P<0.01),C级差异显著(P<0.05),肝硬化患者首次检测的Hcy含量与随访2年后检测的Hcy含量自身比较,Hcy略有增加,呈升高趋势,但无统计学意义(P>0.05)。结论:肝硬化及肝癌病人随着肝细胞损害程度的逐渐加重,血浆Hcy水平逐渐升高,血浆Hcy是反映肝损伤程度较为敏感的生化指标之一,并且对肝硬化及肝癌的诊断、治疗、预后判断具有一定的指导意义。更多还原

【Abstract】 Objective:To investigate the plasma homocysteine(Hcy) detected in patients with liver cirrhosis and liver cancer and the clinical value in patients with liver cirrhosis were followed up for 2 years after the change in plasma Hcy concentration.Methods:137 cases of liver cirrhosis,43 cases of liver cancer patients and 50 control group,plasma Hcy levels in patients with liver cirrhosis after 2 years follow-up testing of plasma Hcy levels of the test results for statistical analysis.Results:The liver cirrhosis and liver cancer group was significantly increased Hcy levels,with statistical significance(P<0.05 or P<0.01),liver cirrhosis patients with Child-Pugh classification and the incremental increase,and the group of liver cancer and liver comparison between the hardening at all levels,A-class,B-class difference was significant(P<0.01),C-level significantly different(P<0.05),first detected in patients with cirrhosis of the Hcy concentration and follow-up 2 years after the detection of Hcy content in their own comparison,Hcy increased slightly,the trend was rising,but no statistical significance(P> 0.05).Conclusion:Patients with liver cirrhosis and the extent of damage to liver cells gradually increase,gradually increased the level of plasma Hcy and plasma Hcy is a reflection of the degree of liver injury is more sensitive biochemical indicator of,and the diagnosis of liver cirrhosis and liver cancer,treatment,prognosis has some significance.更多还原