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白细胞介素在扩张型心肌病患者血清中的表达及意义

Detection and evaluation of the serum interleukins in patients with DCM

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【作者】 李秀玉辛晓敏刘凤岐

【Author】 LI Xiu-yu1,XIN Xiao-min2,LIU Feng-qi3.(1.Department of Laboratory Diagnosis,XuanWu Hospital of the Capital University of Medical Sciences,Beijing 100053,China;2.Department of Laboratory Diagnosis,The First Clinical College,Harbin Medical University,Harbin 150001,China;3.Department of Cardiology,The First Clinical College,Harbin Medical University,Harbin 150001,China)

【机构】 首都医科大学宣武医院检验科哈尔滨医科大学第一临床医学院检验科哈尔滨医科大学第一临床医学院心内科

【摘要】 目的观察扩张型心肌病(DCM)患者血清中的白细胞介素6(IL-6),白细胞介素1α(IL-1α),可溶性白细胞介素-2受体(SIL-2R)及白细胞介素10(IL-10)的水平,探讨其意义。方法扩张型心肌病患者组35例,健康对照组21例,用ELISA方法测定IL-6,IL-1α,SIL-2R,IL-10水平,并对其结果进行比较。结果DCM患者血清中IL-6,IL-1α,SIL-2R及IL-10水平明显高于健康对照组(P<0.05)。结论DCM患者血清中IL-6,IL-1α,sIL-2R及IL-10水平的升高,说明DCM的发生、发展与免疫因素重要相关。

【Abstract】 Objective To observe the concentrations of the serum IL-6、IL-1α,SIL-2R and IL-10 in patients with DCM.Methods The concentrations of the serum IL-6 、IL-1α、SIL-2R and IL-10 were assayed by ELISA in 35 patients with DCM and we compared it with those of 21 age matched healthy control subjects.Results The concentrations of the serum IL-6、IL-1α,SIL-2R and IL-10 were significantly higher in patients with DCM than those in controls(P<0.05).Conclusion The concentrations of the cytokines may suggest that DCM is closely correlated with the immune systerm.

【基金】 黑龙江省“十五”科技攻关项目(GB01C126-03)
  • 【文献出处】 中国实验诊断学 ,Chinese Journal of Laboratory Diagnosis , 编辑部邮箱 ,2009年08期
  • 【分类号】R542.2
  • 【被引频次】3
  • 【下载频次】66
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