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白细胞介素在扩张型心肌病患者血清中的表达及意义
Detection and evaluation of the serum interleukins in patients with DCM
【摘要】 目的观察扩张型心肌病(DCM)患者血清中的白细胞介素6(IL-6),白细胞介素1α(IL-1α),可溶性白细胞介素-2受体(SIL-2R)及白细胞介素10(IL-10)的水平,探讨其意义。方法扩张型心肌病患者组35例,健康对照组21例,用ELISA方法测定IL-6,IL-1α,SIL-2R,IL-10水平,并对其结果进行比较。结果DCM患者血清中IL-6,IL-1α,SIL-2R及IL-10水平明显高于健康对照组(P<0.05)。结论DCM患者血清中IL-6,IL-1α,sIL-2R及IL-10水平的升高,说明DCM的发生、发展与免疫因素重要相关。
【Abstract】 Objective To observe the concentrations of the serum IL-6、IL-1α,SIL-2R and IL-10 in patients with DCM.Methods The concentrations of the serum IL-6 、IL-1α、SIL-2R and IL-10 were assayed by ELISA in 35 patients with DCM and we compared it with those of 21 age matched healthy control subjects.Results The concentrations of the serum IL-6、IL-1α,SIL-2R and IL-10 were significantly higher in patients with DCM than those in controls(P<0.05).Conclusion The concentrations of the cytokines may suggest that DCM is closely correlated with the immune systerm.
【Key words】 Dilated cardiomyopathy; interleukin-6; interleukin-1α; soluble interleukin-2 receptor; interleukin-10;
- 【文献出处】 中国实验诊断学 ,Chinese Journal of Laboratory Diagnosis , 编辑部邮箱 ,2009年08期
- 【分类号】R542.2
- 【被引频次】3
- 【下载频次】66