【摘要】 目的探讨重组人血管抑制因子Vasostatin(120-180aa)对于碱烧伤诱导的家兔角膜新生血管的抑制作用。方法采用1 mol/L NaOH溶液烧伤家兔角膜,建立碱烧伤诱导的家兔角膜新生血管的动物模型;将家兔分为A、B、C、D4组,每组10只眼。伤后24 h后分别给予1×PBS缓冲液,20、40、80μg/mL Vasostatin(120-180aa)球结膜下注射,2次/周,共4周。测量各时间点角膜新生血管的生长面积,观察血管的生长情况。结果各时间点角膜新生血管的面积,B组、C组及D组均低于A组(P<0.05),C组及D组均低于B组(P<0.05),C组与D组相比,差异无显著性(P>0.05)。结论重组人Vasostatin(120-180 aa)蛋白可有效抑制角膜新生血管的形成。更多还原

【Abstract】 Objective To investigate the inhibitory effect of recombinant human vasostatin(120-180aa) on alkaline-induced corneal neovascularization.Methods Corneal neovascularization animal model was established using 1 mol/L NaOH solution in rabbit.The rabbit eyes were divided into 4 groups:A group(10 eyes),B group(10 eyes),C group(10 eyes) and D group(10 eyes).1×PBS solution buffer,20,40 and 80 μg/mL vasostatin(120-180 aa) protein was subconjunctivally injected respectively in rabbits 24 hours after burning for twice a week.The areas of rabbit corneal neovascularization were measured at each time point.Results The areas of corneal neovascularization in B group,C group and D group were significantly lower than that A group at each time point(P<0.05),and those of C group and D group were lower than B group(P<0.05),but there was not significant difference between C group and D group(P>0.05).Conclusion The recombinant human vasostatin(120-180 aa) can effectively inhibit alkaline-induced corneal neovascularization.更多还原