【摘要】 目的探讨前列腺按摩液(EPS)、血清、精浆中白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)在男性不育的作用。方法用ELISA法检测60例慢性前列腺炎(CP)的不育患者EPS、血清、精浆中IL-2、IL-6、TNF-α的水平,20例正常生育男性做对照,并对所获得的数据进行统计学分析。结果伴有前列腺炎不育患者的EPS及精浆中细胞因子IL-2、TNF-α、IL-6的水平明显高于正常男性,差异有极显著性(P<0.001);不育组血清中IL-6及TNF-α值明显高于正常对照组;正常对照组与不育组血清中的IL-2值比较差异无显著性(P>0.05);EPS中IL-2、IL-6及TNF-α各指标与血清及精浆存在正相关,EPS中TNF-α与精浆中TNF-α相关系数r=0.726,P<0.001。结论在慢性前列腺炎症产生的细胞因子是精浆里的主要来源,说明精浆内表达不同的细胞因子可能参与影响精子功能,在不育的发病中起重要的作用。更多还原

【Abstract】 Objective To investigate the levels of cytokine IL-2,IL-8 and TNF-αin the expressed prostatic secretions(EPS),serum and seminal plasma of Infertile men with chronic prostatitis(CP) and to evaluate the significance of the cytokines to the male infertility.Methods IL-2,IL-6 and TNF-αlevels were measured in the EPS,serum and seminal plasma of 60 Infertile men and 20 normal controls by ELISA.,and the results were statistically calculated.Results The IL-2,IL-6 and TNF-α levels of EPS,seminal plasma and the IL-6 and TNF-αlevels of serum in Male Infertile patients were significantly higher(P<0.001) while serum than those in the controls(both P<0.05).There was no statistically significant difference between the IL-2 levels of serum in Male Infertile patients and in controls(P>0.05).The cytokine levels in EPS were correlated directly with those in serum or seminal plasma.The TNF-αlevel in EPS was rwas higher correlated with those in seminal plasma(r=0.726,P<0.001).Conclusion During chronic prostatitis,the inflammatory cytokines in seminal plasma mainly come from EPS may involved in the regulations of sperm function and reduce male fertility function and reduce male fertility.更多还原