【摘要】 目的建立弹性壁兔颈动脉狭窄模型并分析一个心动周期中狭窄动脉内的壁面切应力分布和变化。方法采用显微缝合法建立弹性壁兔颈动脉狭窄模型,多普勒超声和DSA分别测得狭窄血管影像并计算狭窄率,应用计算机流体力学软件Matlab、Ansys、Fluent对狭窄动脉内一个心动周期的血流动力学变化进行可搏动的二维血流动力学数值模拟。结果成功建立弹性壁单侧兔颈动脉狭窄模型并模拟一个心动周期中的切应力(WSS)分布和变化。WSS在收缩中期时最大,在狭窄处及狭窄远心端分别形成高WSS和低WSS区。一个心动周期中狭窄处WSS变化最大,狭窄远心端WSS变化最小。随狭窄率增加,狭窄远心端WSS减小并逐渐趋近于0。结论数值模拟能够较好的反应颈动脉狭窄的WSS分布和变化,为临床提供理论依据。更多还原

【Abstract】 Objective To establish carotid artery stenosed model in rabbit and assess wall shear stress(WSS) distribution in this animal model.Methods We made carotid artery stenosed model in rabbit by partial microsurgical suture.We got the image of the angiostenosis by doppler ultrasound and digital subtraction angiography(DSA) then came to the ratio of stenosis.Computational fluid dynamics simulation(CFDS)was performed in the carotid artery stenosed model in a whole cardiac cycle with the application of softwares as Photoshop,Matlab,Ansys and Fluent.Results Elastic carotid artery stenosed model in rabbit were successfully performed.Hemodynamics features including wall shear stress distribution in 2-dimensional pulsating carotid artery stenosed model were well discribed in a whole cardiac cycle.We found WSS changed with blood flow rate and peak at mid contraction of a cardiac cycle.High WSS and low WSS were found in the position of stenosis and the post-stenotic part respectively.The range of WSS was maximum at the position of stenosis while minimum at the extremal part of the stenosis.As the ratio of stenosis promoted,WSS at the position of extremal part of the stenosis decreased and closed to 0.Conclusion CFDS is a good method to discribe WSS distribution in carotid artery stenosed model which provides theoretical evidence for clinical.更多还原