【摘要】 为研究大黄注射液对犬动脉搭桥术后血液流变学参数的影响,将20只试验犬随机分为高(0.8 g/kg)、中(0.4g/kg)、低(0.08 g/kg)剂量组及对照组,同侧自体颈外静脉45°重建颈总动脉,术后头静脉滴注大黄注射液,分别于给药前、给药后1、2周测定血液流变学各参数的变化。结果显示,高、中、低剂量大黄注射液均能极显著降低低切(10 s-1)时全血黏度,高、中剂量大黄注射液还能显著或极显著降低中、高切(60 s-1、150 s-1)时全血黏度;低剂量和高剂量大黄注射液对全血还原黏度无显著影响,而中剂量大黄注射液能显著降低全血还原黏度;高、中、低剂量大黄注射液在用药2周后均能显著降低血浆黏度;低剂量和高剂量大黄注射液对红细胞聚集指数、红细胞刚性指数和红细胞变形指数无显著影响,而中剂量大黄注射液在用药后2周能显著降低红细胞聚集指数;3种剂量大黄注射液对红细胞压积、红细胞电泳指数无显著影响。结果表明,中剂量大黄注射液能显著改善犬动脉搭桥术后血液流变学特性。更多还原

【Abstract】 In order to observe the effects of Rhubarb injection on blood hemorrheological parameters after bypass vascular surgery,20 hybrid dogs were divided into high,middle,low dosage group(0.8,0.4 and 0.08 g/kg)and control group.The common carotid artery was reconstructed with jugular vein from the same side by 45° bypass vascular surgery.Rhubarb injection was intravenously transfused through vena cephalica.The hemorrheological parameters were detected at pre-medication,1 and 2 weeks after drug administration.Results were as follows:(1) All dosage of rhubarb injection could extremely reduce the whole blood viscosity at low shear rate(10 s-1),middle and high dosage could also significantly or extremely reduce the whole blood viscosity at middle and high shear rate(60 s-1,150 s-1).(2) Low and high dosage had no effects on whole blood reductive viscosity,but middle dosage of could significantly decrease the whole blood reductive viscosity;(3) All dosage could significantly reduce plasma viscosity after 2 weeks administration.(4) Low and high dosage had no influence on erythrocyte aggregation index,erythrocyte rigidity index,erythrocyte deformation index,but middle dosage could significantly decrease erythrocyte aggregation index.(5) All dosage had no influence on hematocrit and erythrocyte electrophoresis index.In brief,middle dosage could significantly improve hemorrheological feature of dogs after bypass vascular surgery.更多还原