【摘要】 【目的】探讨选择性头部亚低温治疗新生儿缺氧缺血性脑病临床疗效。【方法】将40例生后6 h内确诊为新生儿缺氧缺血性脑病(HIE)的足月儿随机分为对照组、亚低温组各20例,两组患儿均采用稳定内环境,维持血压、血糖、血流灌注、通气、止痉、对症、降低颅内压、消除脑干症状、护脑等综合治疗;亚低温组加用在出生后6 h内进行头部亚低温治疗72h后再复温。观察两组患儿治疗前、中、后血生化(血电解质及心肝肾功能)变化及神经系统症状发生率,比较两组患儿生后7、14、28 d的NBNA评分。【结果】两组治疗前、中、后生化指标变化差异无统计学意义(P>0.05);与对照组比较,亚低组治疗中后神经系统症状发生率低于对照组,亚低温组生后7、14、28 d的NBNA评分高于对照组,差异有统计学意义(P<0.05)。【结论】选择性头部亚低温治疗新生儿HIE是有效的,具有近期及远期的神经保护作用。更多还原

【Abstract】 [Objective]To study the effect of elective cephalic hypothermia treatment on newborn hypoxic ischemic encephalopathy(HIE).[Methods]Forty normal term infants with HIE within 6 hours after birth were served as therapeutic group,The other cases with HIE were served as the control group.Two groups of infant maitained stable internal environment, blood pressure,blood sugar,blood perfusion,ventilation,treating convulsions and reduce intracranial pressure and eliminate the symptoms of brain stem,retaining the treatment of brain,such as general.The therapeutic group was treated by elective cephalic hypothermia for 72 hours.The treatment started within 6 hours after birth.The Blood Biochemical Indexes were monitored. [Results]Compared with the control group,therapeutic group had no difference of Blood Biochemical Indexes(P>0.05). However,it reduced the incidence of nervous system,symptoms in therapeutic group(P<0.05).[Conclusion]The treatment of HIE with elective cephalic hypothermia is effective,with the function of nervous protection for short and long term.更多还原