【摘要】 【目的】观察阿米福汀对放射性口干的防治作用。【方法】对30例鼻咽癌患者随机分为两组,两组患者均接受70Gy的放射治疗,治疗组每次放疗前20min静脉注射阿米福汀,剂量为200mg/m2,对照组则没有注射阿米福汀直接放疗,观察两组患者唾液量的变化、毒性反应率及放疗的疗效。【结果】两组患者均出现较高放射性口干发病率,但治疗组唾液分泌量明显多于对照组(P<0.05),放射性粘膜炎也明显少于对照组,但消化道反应较对照组严重。两组患者鼻咽癌的放疗有效率均为100%,阿米福汀未影响放疗疗效。【结论】阿米福汀对鼻咽癌放疗患者的唾液腺有一定保护作用,同时对肿瘤组织无保护作用。更多还原

【Abstract】 【Objection】 To evaluate amifostin effect on preventing radiation-induced xerostomia.【Methods】 Thirty patients with NPC were divided into groups randomly.Radiation therapy(70 Gy) was given to all the patients.Amifostine was injected into the patients before 20 min in the treatment group.Amifostine was instead by 0.9% NS.The salivary quantity, therapeutic effect and side-effect were evaluated respectively.【Results】 The salivary quantity in treatment group was remarkably higher than that in control group(P < 0.05).The catarrh of oral cavity in the treatment group was more serious than that in control group.On the other hand, the side-effect of digestive tract in control group was more serious than that in the treatment group.There was no difference between the both groups.【Conclusion】 Amifostine is able to effectively protect salivary gland from radiation therapy due to NPC.At the same time, amifostine shows no protect to tumor tissue.更多还原