【摘要】 【目的】分析中国南方汉族人群9个STR基因座的遗传多态性。【方法】用STR_Typer₁0_v1荧光标记试剂盒,对1619例中国南方汉族无关个体的9个STR基因座（D11S2368,D12S391,D13S325D18S1364,D22-GATA198B05,D6S1043,D2S1772,D7S3048,D8S1132）进行扩增,用AB公司3100遗传分析仪和GeneMapper 3.1v软件作STR分型,用PowerStateV12.xls分析软件进行等位基因频率和法医学常用参数统计分析,用Arlequin 3.11v软件包作Hardy-Weinberg equilibrium平衡检验。【结果】在中国南方汉族人群中,该9个STR基因座的遗传多态性高,杂合度（H）分布在0.818～0.879之间,随机匹配（MP）率分布在0.031～0.063之间,个体识别力（PD）在0.937～0.970之间,非父排除率（PE）在0.632～0.753之间,多态性息含量（PIC）在0.80～0.88之间,典型父权指数（TPI）在2.74～4.13之间。统计分析证明这些群体资料均达到Hardy-Weinberg equilibrium（P>0.05）。【结论】中国南方汉族人群9个STR基因座具有较高多态性,可以用于法医学亲权鉴定和个体识别,也可以用于人类学和遗传学研究。更多还原

【Abstract】 【Objective】 To investigate the genetic polymorphism of nine short tandem repeat（STR） loci in Han population of Southern China.【Methods】 The 9 STR loci（D11S2368,D12S391,D13S325,D18S1364,D22-GATA198B05,D6S1043,D2S1772,D7S3048,D8S1132） were amplified with STR_Typer₁0_v1 kit for 1619 unrelated individuals of Han population in Southern China.The PCR products were analyzed with 3100 genetic analyzer and GeneMapper ID 3.1v software.The forensic efficiency parameters were calculated by PowerState V12.xls and the Hardy-Weinberg equilibrium was tested with Arlequin 3.11v software.【Results】 The genetic polymorphism of 9 STR loci in Han population of Southern China was quite high.The heterozygosities（H） ranged from 0.818 to 0.879.The match probabilities（MP） ranged from 0.031 to 0.063.The powers of discrimination（PD） ranged from 0.937 to 0.970,the probabilities of exclusion（PE） ranged from 0.632 to 0.753,the polymorphism information contents（PIC） ranged from 0.80 to 0.88 and the typical paternity indices（TPI） ranged from 2.74-4.13,respectively.These data were in accord with Hardy-Weinberg equilibrium（P > 0.05）.【Conclusion】 Nine STR loci are highly polymorphic in Chinese Han population.They are new useful tools for paternity testing,individual identification,and for the research of human genetics and anthropology.更多还原