【摘要】 目的探讨静脉注射免疫球蛋白(intravenous immunoglobulin IVIG)对重症肌无力(myas-thenia gravis,MG)细胞免疫机制的影响,为临床提供理论基础。方法采用IVIG治疗MG患者12例,在IVIG治疗0天和治疗后第5天,观察MG肌无力临床绝对评分及治疗前后INF-γ、IL-4变化。结果IVIG治疗后,临床绝对评分(15.083±3.204)下降,与治疗前(19.083±2.539)比较P<0.01;INF-γ阳性细胞数(0.857±0.176)下降、IL-4阳性细胞数(0.699±0.138)增加,与治疗前(1.035±0.235,0.584±0.129)比较均P<0.05。结论IVIG治疗MG患者能有效改善MG患者肌无力症状,抑制Th1细胞因子分泌,促进Th2细胞因子分泌。更多还原

【Abstract】 Objective To investigate Effection of intravenous immunoglobulin(IVIG) on cell immunity mechanism of myasthenia gravis (MG)patients and provide a theory basis for clinical medication.Methods Twelve MG patients were treated for 5 days with IVIG and evaluated the clinical severity of MG at the day before treatment and the 5th day after treatment by Xu’s clinical scoring system,the INF-γ and IL-4 positive peripheral blood lymphocyte were determined by flow cytometry.Results Compared with pretherapy,the clinical score of MG were decreased post-treatment(19.083±2.539),(15.083±3.204),(P<0.01),the INF-γ and IL-4 positive peripheral blood lymphocyte were lower post-treatment(1.035±0.235),(0.857±0.176),(P<0.05)and the INF-γ and IL-4 positive peripheral blood lymphocyte were increased post-treatment(0.584 ±0.129),(0.699±0.138),(P<0.05).Conclusion The symptom of MG patients can be ameliorate by treated with IVIG..Inhibits production of Th1 cytokines and promotes production of Th2 cytokines maybe the probably mechanism.更多还原