【摘要】 目的:研究青蒿抗热应激作用及其机理。方法:利用高温高湿环境造成家兔热应激模型,观察青蒿总香豆素对家兔肛温上升及血液、肺组织磷脂酶A2活性和循环内皮细胞数目的变化,并测定其对脑、心脏、肾组织钠泵活性及小鼠抗脑缺氧能力的影响。结果:青蒿总香豆素可明显降低热应激家兔体温上升速度,并伴随血清、肺组织磷脂酶A2活性降低,循环内皮细胞减少,显著抑制脑、心、肾组织钠泵活性,延长断头小鼠张口喘气时间几近1倍。结论:香豆素部位可能是青蒿祛暑功效的活性成分群之一。更多还原

【Abstract】 Objective:To study the Anti-heat-stress activity and related mechanisms of total coumarins（TCs）from Artemisia annua.Methods: Heat stress rabbit model caused by high temperature and high humidity was used and rectal temperature（Tr） responses,PLA₂ activity in blood and lung,circulating endothelial cells（CECs） were measured,moreover,Na⁺,K⁺-ATPase activity in brain,kedney and heart in rabbits was assayed,gasping time after decapitation in mice was observed after treatment of total coumarins（TCs） from Artemisia annua.Results: Administration of TCs reduced the rise of rectal temperature and CECs in heat stress rabbits,inhibited the activity of the PLA₂ and Na⁺,K⁺-ATPase,increased the gasping time in mice.Conclusion: Coumarins are one of anti-heat-stress active fractions in Artemisia annua.更多还原