【摘要】 目的评价左乙拉西坦(LEV)治疗小儿癫痫的疗效和安全性。方法2007年8月至2008年8月武汉市儿童医院神经内科病房和门诊收治的56例癫痫患儿口服LEV片。其中32例单药治疗;24例添加治疗,即在原有抗癫痫药物剂量及用法不变的基础上添加LEV口服。起始剂量为5.2～20.8mg(/kg·d),2次/d;目标剂量为14.4～41.6mg(/kg·d),2次/d。随访时间为3～12个月。结果LEV单药治疗有效率为68.8%,无发作率为40.6%,添加治疗有效率为41.7%,无发作率为8.3%。两组比较差异有统计学意义(P<0.05)。LEV副反应较少,主要为胃肠不适、头晕、嗜睡、易激惹等。结论LEV治疗儿童癫痫有效,单药治疗疗效高于添加治疗,患儿对其有较好的耐受性。更多还原

【Abstract】 Objective To evaluate the therapeutic effect and safety of levetiracetam(Keppra).Methods A total of 56 children with epilepsy between the ages of 5 months and 14 years were treated with levetiracetam.There were 32 cases by monotherapy and 24 cases by add-on therapy.The starting dosage of levetiracetam was 5.2～20.8 mg/kg of tablet per day twice daily,and its objective dosage was 14.4～41.6 mg/kg per day twice daily in children with epilepsy.The follow-up period ranged from 3 to 12 months.Results The effective rate(> or = 50% reduction in seizures) was found in 68.8%,with 40.6% achieving seizure freedom in monotherapy of levetiracetam.The effective rate was found in 41.7%,with 8.3% achieving seizure freedom in add-on therapy of levetiracetam.The effective rate of monotherapy of levetiracetam showed significant difference as compared with add-on therapy(P<0.05).There were mild adverse reactions in levetiracetam treatment of children with epilepsy,including gastrointestinal dysfunction,dizziness,somnolence and irritability,etc.Conclusion The levetiracetam is effective as monotherapy and as add-on therapy,and well tolerated for epilepsy in children.The efficacy of monotherapy is higher than that of add-on therapy in levetiracetam treatment of children with epilepsy.更多还原