【摘要】 合成了三类取代哌嗪修饰的新型联苯哌嗪化合物,并对这些化合物进行多级电喷雾-离子阱质谱裂解分析。在一级全扫描质谱中发现,三乙胺与4,4′-二甲氧基-5,6,5′,6′-二次甲二氧基联苯-2-甲酸酯-2′-甲酰基-4-取代哌嗪化合物形成[M+101+H]+。实验还发现,结构中有氟原子存在的联苯-2-甲酸酯-2′-甲酰基-4-取代哌嗪化合物更易与钠离子结合形成加钠的准分子离子[M+Na]+。二级质谱说明,4,4′-二甲氧基-5,6,5′,6′-二次甲二氧基联苯-2-甲酸酯-2′-甲酰基-4-取代哌嗪化合物的哌嗪上取代基的不同,对二级质谱的碎片离子形式有显著的影响。更多还原

【Abstract】 Three kinds of novel biphenyls modified by substituted piperazines were synthesized.These biphenyls were studied by electrospray ionization-trap mass spectrometer(ESI-MS).The result of MS indicates that the target compounds a-f form complex ions with triethyl amine through hydrogen ion [M+101+H]+ in ESI-MS.The biphenyls bearing fluorine atom also combine with Na+ to form molecular ion + easilier than others.The result of MS2 shows that the different substituent of piperazine has more effect on ESI-MSn.更多还原