【摘要】 目的探讨肝移植治疗肝细胞型肝癌的术后存活率及其影响因素。方法回顾分析8年来89例接受肝移植治疗且随访时间≥6个月的肝细胞型肝癌患者的临床资料。计算患者术后1,2,3年生存率,并通过单因素和多因素分析寻找影响存活率的影响因素。结果89例患者肝移植术后1,2,3年存活率分别为91.2%,68.5%,59.4%;单因素分析显示,肿瘤最大径、门静脉癌栓、肿瘤分化程度和肿瘤TNM分期是影响存活率的重要因素;Cox风险模型多因素分析显示,肿瘤最大径、肿瘤分化程度和肿瘤TNM分期均是影响存活率的独立危险因素。结论肝移植是目前治疗肝细胞型肝癌的有效方法;肿瘤最大径>5cm、肿瘤分化程度差和肿瘤TNM分期高均会严重影响患者的存活率。更多还原

【Abstract】 Objective To evaluate the survival and prognostic factors of orthotopic liver transplantation(OLT)for hepatocellular carcinoma(HCC).Methods Eighty-nine HCC patients who underwent OLT in our hospital from August 2000 were followed up more than 6 months,and their clinical and follow up data were retrospectively analyzed.Results The 1-,2-,and 3-year cumulative survival rate of the 89 patients was 91.2%,68.5% and 59.4% respectively.Univariate analysis revealed that the size,the presence of portal vein tumor thrombus,histological differentiation and pTNM stage were statistically significant factors affecting survival.Multivariate analysis using Cox proportional hazards regression model demonstrated that the size and the presence of portal vein tumor thrombus were independent and statistically significant factors affecting survival.Conclusions OLT is an effective treatment for HCC patients.Tumor diameter >5 cm,poor histological differentiation and high pTNM stage significantly affect the survival of these patients.更多还原