【摘要】 目的探讨结缔组织生长因子(connective tissue growth factor,CTGF)在结直肠癌组织中的表达及临床意义。方法采用免疫组化法检测62例结直肠癌及其对应的癌旁组织中CTGF的表达,并对结果进行统计学分析。结果CTGF在结直肠癌组织和癌旁组织中表达阳性率分别为61.3%(38/62)和19.4%(12/62),其在结直肠癌组织中的表达明显高于其癌旁组织(P<0.05)。CTGF在结直肠癌组织中的表达与其分化程度、浸润深度及淋巴结转移有关,即癌组织分化程度越低,CTGF表达阳性率越低(P=0.030),随癌组织浸润深度的加深而CTGF表达阳性率明显降低(P=0.032),有淋巴结转移者CTGF的表达阳性率明显低于无淋巴结转移者(P=0.017),而与性别无关(P>0.05)。结论CTGF在结直肠癌的发生、发展过程中可能起重要作用,对指导临床治疗和判断预后有重要意义。更多还原

【Abstract】 Objective To investigate the expression and clinical significance of connective tissue growth factor(CTGF) in colorectal cancer.Methods The expressions of CTGF in 62 patients’ colorectal cancer tissues and their corresponding adjacent tissues were detected by SP immunohistochemical method.The results were statistically analyzed.Results The positive rates of CTGF in colorectal cancer and adjacent tissues were 61.3% and 19.4% respectively,and the difference between them was significant(P<0.05).The expression of CTGF was related to degree of differentiation,depth of infiltration and lymph node metastasis or not(P<0.05),namely the lower degree of differentiation,the deeper depth of infiltration and the more lymph node metastasis,the corresponding positive expression rates were lower(P=0.030,P=0.032 and P=0.017 respectively),but correlation with gender was not significant(P>0.05).Conclusion CTGF may play an important role in the occurrence of colorectal cancer,which contributes a lot to guide clinical treatment and prognosis.更多还原