【摘要】 目的探讨碳酸锂对Graves甲亢患者甲状腺131I摄取率的影响及监测碳酸锂使用前后血、尿β2-微球蛋白的水平,了解碳酸锂对肾功能的影响。方法对68例131I摄取率<50%的Graves甲亢患者,在给予碳酸锂(250 mg.次-1,3次.d-1)1周前后,分别测定131I摄取率,以观察碳酸锂对131I摄取率的影响及治疗前后血、尿β2-微球蛋白的水平。结果68例患者服碳酸锂1周后,最高131I摄取率达到73.8%,131I摄取率平均由28.5%±11.7%上升至43.4%±18.3%,平均较原有水平提高14.9%±9.4%(P<0.001);而治疗前后血、尿β2-微球蛋白水平无明显变化。结论碳酸锂能有效提高131I摄取率不够高的Graves甲亢患者的131I摄取率,且肾功能正常时,使用碳酸锂1周对Graves病患者肾功能无不良影响。更多还原

【Abstract】 Objective To investigate the lithium carbonate in patients with hyperthyroidism of Graves thyroid 131I uptake rate and monitoring the effect of lithium before and after the use of blood and urine β2-microglobulin level,and to understand the effect of lithium carbonate on renal function.Methods A total of 68 patients with 131I uptake rate <50% with Graves hyperthyroidism,after receiving lithium carbonate 250 mg tid,1 week before and after 131I uptake were determined.We observed the effect of lithium carbonate on the uptake rate of 131I and treatment before and after blood and urine β2-microglobulin level.Results One week after lithium carbonate in the patients the maximum rate of 131I uptake reached 73.8%,and 131I uptake rate rose from an average of 28.5% ± 11.7% to 43.4% ± 18.3%,14.9% ± 9.4% higher than before(P <0.001).There was no significant change before and after the treatment in blood and urine β2-microglobulin level.Conclusion Lithium can effectively improve the 131I uptake rate in patients with Graves hyperthyroidism.The use of lithium carbonate for 1 week in patients with Graves does not have adverse affect on normal renal function.更多还原