【摘要】 目的观察注射用奥扎格雷钠(丹奥)联合银杏达莫治疗急性脑梗死的疗效及其对血液流变学的影响。方法将92例急性脑梗死患者随机分为治疗组与对照组各46例。治疗组采用丹奥80 mg+0.9%氯化钠注射液250 mL,银杏达莫注射液20 mL+0.9%氯化钠注射液250 mL,均为1次.d-1治疗,疗程14 d;对照组采用血塞通注射液20 mL+0.9%氯化钠注射液250 mL,丹参注射液20 mL+0.9%氯化钠注射液250 mL静滴,均为1次.d-1,疗程14 d,2组其余治疗相同。治疗前及治疗2周后分别进行2组患者的临床神经功能缺损程度评分及血液流变学指标检测。结果治疗组临床显效率95.7%,明显优于对照组(80.4%)(P<0.05);2组治疗后神经功能缺损程度比较有显著性差异(P<0.05);治疗组治疗后血液流变学指标比治疗前显著下降(P<0.05);2组治疗后血液流变学指标有显著性差异(P<0.05)。结论奥扎格雷钠联合银杏达莫治疗急性脑梗死有明显疗效,并能明显改善急性脑梗死患者的血液流变学指标。更多还原

【Abstract】 Objective To explore the curative effect of ginkgo dipyridolum and ozagrel for acute cerebral infarction and its influence on blood rheology.Methods A total of 92 cases of acute cerebral infarction were randomly diveded into 2 groups:46 in a treatment group were treated with ozagrel 80 mg+250 mL saline and ginkgo dipyridolum injection20 mL +250 mL saline intravenously,and 46 in a contrast group with Xuesaitong 20 mL +250 mL saline and salvia 20 mL+250 mL saline intravenously,once daily for 14 days.The score of neurological deficit was evaluated to assess the clinical efficiency,and the changes of indexes of blood rheology in the two groups were observed before and after the treatment.Results Total effective rate(95.7%)in the treatment group was signifcantly higher than that in the contrast group(80.4%)(P<0.05).Compared with those before the treatment,the indexes of blood rheology in the treatment group decreased significantly after the treatment(all P<0.05).There were significant differences in the 2 groups after the treatment in the indexes of blood rheology(P<0.05).Conclusion The combination of ozagrel and ginkgo dipyridolum acute cerebral infarction can produce good curative effect and improve the indexes of blood rheology.更多还原