【摘要】 目的:与氯硝西泮合并奎硫平相对照,观察奎硫平合并无抽搐电休克治疗精神分裂症急性兴奋的疗效和不良反应。方法:64例精神分裂症急性期兴奋患者,随机分为肌内注射氯硝西泮组和无抽搐电休克组,均按常规口服奎硫平,疗程均为14天。治疗期间(定时)评估阳性和阴性症状量表(PANSS)、兴奋因子(PANSS-EC)和治疗中需要处理的不良反应量表。结果:无抽搐电休克组与氯硝西泮组比较,经重复测量分析结果显示PANSS-EC分,差异无显著性(t1.32,P=0.196)。两组患者的急性兴奋症状均获得明显缓解(P<0.01),不良反应出现率相似。结论:奎硫平合并无抽搐电休克和肌内注射氯硝西泮疗效相似,不良反应发生率相近。更多还原

【Abstract】 Objective:To investigate the efficacy and adverse effect profiles of Quetiapine combined with intramuscular Clonazepam or MECT in the treatment of acute excitement in schizophrenia. Methods:A total of 64 schizophrenics with moderate acute excitement were randomized to receive Quetiapine combined with Clonazepam or MECT. The patients were simultaneously assessed with the Positive and Negative Syndrome Scale Excited Components (PANSS- EC) and Treatment Emergent Signs and Symptoms (TESS) every day. Results: The efficacy of Quetiapine combined with Clonazepam was comparable to MECT (t = 1.32 P = 0. 196). Acute excitement in schizophrenia was significantly improved within each group (P < 0.01 ). The side effects were was not significantly difference. Conclusions: Quetiapine combined intramuscular Clonazepam was effective and safe to control acute excitement of schizophrenia and less side effects.更多还原