【摘要】 目的观察人参二醇组皂苷(PDS)对感染性休克大鼠血液流变性及微循环的影响,探讨其抗感染性休克的作用机制。方法大鼠舌下静脉注射PDS进行预治疗,10min后注射细菌内毒素(LPS5mg/kg)复制感染性休克模型。实验动物随机分为对照组(S组);内毒素休克模型组(L组);地塞米松预治疗组(LD组);PDS预治疗(22.5mg/kg,LP小)(45mg/kg,LP中)(90mg/kg,LP大)组。各组于休克后观察肠系膜微循环的变化,2h和4h腹主动脉取血,测量全血黏度。结果模型组在休克2h、4h全血黏度明显高于PDS各剂量组(P<0.01)。肠系膜微循环的变化:PDS各剂量组在休克2～4h微动脉管径、微动脉血流速度及微动脉管袢数均高于模型组(P<0.05)。结论PDS通过降低内毒素休克大鼠全血黏度,改善微循环状态,起到抗休克的作用。更多还原

【Abstract】 Objective To observe the effects of panaxadiol saponin (PDS) on blood rheology and microcirculation of septic shock rats,and explore its anti-septic-shock mechanism.Methods Rats were given pre-treatments by sublingual venous injection of PDS and were injected lipopolysaccharide (LPS 5 mg/kg) 10 min later to generate the septic shock models.Experimental rats were randomly divided into LPS,LPS+dexamethasone(Dex),LPS+PDS (lps:22.5,lpm:45,lph:90 mg/kg ) and sham group,respectively.The shocked rats of different groups were observed the changes of mesenteric microcirculation and were drawn blood from abdominal aortas 2 and 4 h later to measure the whole blood viscosity.Results After being shocked 2 and 4 h,the blood viscosity of LPS group was obviously higher than that of PDS groups (P<0.01).The variation of mesenteric microcirculation,including the diameter,blood velocity and loop numbers of arterioles of LPS+PDS groups were all higher than those of LPS group (P<0.05).Conclusions PDS can improve the microcirculation state of LPS-shock rats by decreasing the whole blood viscosity.更多还原